Business
Murrieta Genomics Spinout simplSEQ Completes Seed Round Funding
Company Plans Commercial Operations in 2021
Murrieta Genomics, the launchpad for genomic sequencing startups, has announced that simplSEQ, an incubator company, has completed its seed round funding, having received $2 million in total. Funds are to be used to validate the company’s novel sample preparation technology with external labs, further protect its patent-pending intellectual property and bring the first products to market.
“This is the amount we targeted to get to revenue generation,” stated John Powers, CEO of simplSEQ. “Our first product is a kit for the purification and isolation of nucleic acids from plasma that we believe will transform the genomic industry.”
Powers went on to explain that simplSEQ is initially focused on Nucleic Acid purification and Targeted Assays. The first product is designed to allow labs to isolate and purify virtually all DNA and RNA from biological samples in a completely different way than currently used. The company believes that its proprietary process will be a significant improvement over the existing conventions.
According to simplSEQ’s Chief Science Officer, Brandon Young, “My years at the bench led to a growing frustration with the status quo, accepting products with known issues and increasing complexity of sample preparation and I knew there had to be a better way. simplSEQ’s patent-pending approach eliminates error prone steps and improves turnaround time while reducing lab and labor costs.”
The first product being developed targets the fast-growing liquid biopsy segment. Targeted therapies based upon genomic biomarkers, disease recurrence monitoring, noninvasive pregnancy screening and early cancer screening are just a few of the areas this segment covers. Having a simple protocol that can improve cell free DNA yields while reducing PCR bias and eliminating hybridization and capture steps would be a significant advance. The simplSEQ process also co-purifies both DNA and RNA – enabling simultaneous downstream assays. In addition, no redesigned primers or informatics are needed.
“The clinical use of the cell free DNA has expanded since the initial use with non-invasive prenatal testing. The use of liquid biopsy in oncology has significantly increased since the first commercially available multigene liquid biopsy platform became available in 2014,” stated Dr. John Spinosa, Chief Medical Officer of simplSEQ. “Today several assays with cfDNA in oncology are commercially available and FDA-approved, and a subset of these assays are considered sufficient for treatment eligibility by insurance companies. We expect to see high growth in the applications of cfDNA as precision medicine advances.”
Another market segment simplSEQ intends to transform is the targeted next generation sequencing assay market. This rapidly expanding area is producing new applications in areas such as transplant surveillance, oncology, rare diseases, population genetics and pathogen detection.
“Our process enables improved targeted sequencing by eliminating the need for ligation and reducing GC content bias. We only need a single PCR step, no capture steps and there are no complicated high temperature wash steps. This will eliminate the need for highly trained lab personnel while reducing labor and sequencing costs. Lab turnaround times will be significantly improved and by eliminating steps that may lead to errors, the labs should be able to improve data quality,” explained Young.
One feature that is unique to simplSEQ’s process is that the nucleic acids are covalently bound to a support structure as single strands. This enables complimentary copies of each strand to be made and eluted off. The eluted strands can then be used for testing. The original DNA or RNA remains bound to the solid support and can be reinterrogated.
“As a pathologist, I am acutely aware of how precious samples can be,” said Dr. Spinosa. “The ability to preserve the original nucleic acid material while assaying a sample may eliminate the need for second biopsies if further interrogation is needed. One can go back to the original isolated sample. Dealing with scarce samples and limited time is becoming a larger and larger issue in the pathology community. The ability to test a nucleic acid sample in multiple ways while preserving the original material would be a huge benefit. One can easily envision step-wise assays and the potential of creating a biobank that patients can return to as their care may dictate.”
The company is currently in discussions with industry-leading organizations that have expressed a desire to evaluate the new technology and will thus provide validation on the data that has been generated internally by the company. Upon receiving data and feedback from these organizations, simplSEQ is prepared to go to market.
“We already have manufacturing, fulfillment, delivery and billing in place,” stated Powers. “We will have the ability to scale rapidly, as these operations are being outsourced to leaders in their respective areas. We also believe that many of our larger future customers will want to license the technology for use in their applications. This funding marks a pivotal step in simplSEQ’s development.”
Murrieta Genomics CEO, Jay Goth, stated “This is a perfect example of the kind of genomic sequencing companies we want to launch from our incubator. We are looking for transformational companies that can make an impact in this nascent space. Our advisory board has been instrumental and even critical to the development of simplSEQ. I can tell you that without the entire MG team simplSEQ would not be where it is today.”
Empowering Economic Growth: CALED Conference Set to Unite Industry Leaders in Ontario
CALED’s ‘Growing Local Economies from the Ground Up’ Conference is being held in Ontario at the DoubleTree by Hilton Hotel Ontario Airport on May 7-9. This event is co-hosted by the City of Ontario and San Bernardino County, with Jennifer McLain Hiramoto, CALED’s Chair of the Board and Derek Armstrong respectively representing their city and county as Co-Chairs of the event.
With over 950 members and 45 years of empowering economic developers, CALED is the largest economic development association in the country and the annual conference is the number one place to meet and connect with the boots-on-the -ground, decision makers in our communities.
The conference will include a pre-conference teaching tour, ‘Building & Paying for Development Projects’ on May 6th and then begin in full on May 7th, with a welcome session and breakouts. Overall, there will be four general assembly sessions and 18 breakout sessions, which will delve into local economic development practices and innovative tools.
In addition to compelling content, the conference will have numerous opportunities to connect with community leaders and valued peers through networking receptions, the culinary crawl, and new this year, the Tournament of Champions, where conference attendees will navigate a gauntlet of games to win the grand prize on the evening of Thursday, May 8th.
To learn more about the conference and register, visit the CALED website at www.caled.org.
Business
Strengthening Community Connections: Our Exciting New Partnership with Toyota Arena, Ontario Convention Center, and GOCAL
Contributed Content | By Chris Venhoff, Senior Vice President and Inland Empire Market Leader for Consumer and Business Banking at U.S. Bank
As the Inland Empire market leader for U.S. Bank, I’m thrilled to share some exciting news: we are proud to be the Official Bank Partner of Toyota Arena and Ontario Convention Center. This partnership represents a reflection of our deep commitment to the Inland Empire and our dedication to fostering a vibrant, thriving community.
At U.S. Bank, we believe that strong partnerships drive meaningful progress. Toyota Arena and Ontario Convention Center are at the heart of the region’s culture and economy, bringing people together for world-class entertainment, business conventions, and community events. By joining forces, we’re not only expanding our presence but also creating opportunities to engage with residents, businesses, and organizations in ways that make a lasting impact.
Through our sponsorship, we’ll support concerts, sporting events, and conventions that showcase the diversity and energy of the Inland Empire. But this is only the beginning. As our partnership evolves, we’ll work closely with Toyota Arena, Ontario Convention Center, and GOCAL to introduce community-focused programs, including financial literacy workshops and charitable giving initiatives.
This partnership is designed to bring added value to the people we serve. For our customers, we’re introducing the U.S. Bank Fast Pass Lanes, providing priority access at Toyota Arena events. Special offers, exclusive event experiences, and tailored financial solutions for businesses operating in the region are just a few of the many perks we’re excited to roll out.
Our employees are at the core of our success, and this partnership allows us to recognize their dedication. Through exclusive access to events, corporate hospitality opportunities, and community volunteer programs, our team will have new ways to engage with and celebrate the community they serve.
The Inland Empire is a dynamic, fast-growing region, and we’re committed to supporting its continued success. By investing in Toyota Arena and Ontario Convention Center, we’re helping to create and sustain jobs while driving local business growth. These venues bring in visitors, revenue, and visibility, strengthening the region’s economy.
This collaboration is about more than just sponsorship—it’s about making a difference. By working together, we can elevate not just these venues but the entire Inland Empire. At U.S. Bank, we’re committed to being a partner in progress, supporting our customers, businesses, and communities every step of the way.
Honoring Visionary Leaders Driving Innovation and Community Impact
The Spirit of the Entrepreneur Awards Gala, held at the Riverside Convention Center, celebrated the brightest entrepreneurial talent across the Inland Empire. Among the evening’s finalists was Edward Ornelas, Jr., President & CEO of the Inland Empire Regional Chamber of Commerce, who was honored in the Social Entrepreneur category for his outstanding leadership and commitment to the region.
Although Ornelas did not win, the Social Entrepreneur award went to Cesar Navarrete, President & CEO of Children’s Fund, a proud Chamber member. “Being a finalist alongside such remarkable leaders is an incredible honor,” said Ornelas. “I am especially thrilled to see Cesar, a Chamber member, recognized for the transformative work he’s doing to improve the lives of children in our community. It’s a proud moment for us all.”
Another highlight of the evening was the recognition of Hilda Kennedy, President & Founder of AMPAC Business Capital, another Chamber member, who was awarded the Top Female Entrepreneur category. Hilda’s leadership at AMPAC, a mission-driven business lender, has been instrumental in empowering small businesses and fostering economic growth across the region.
“It’s amazing to see leaders like Hilda and Cesar being celebrated for their contributions,” added Ornelas. “Their achievements underscore the talent and dedication of entrepreneurs in our Chamber and across the Inland Empire. They are setting the standard for excellence and impact in their fields.”
The evening also featured the prestigious “Best of the Best” Award, sponsored by Best Best & Krieger LLP, which was awarded to Mauro Gomez, Chief Growth Officer of Anita’s Mexican Foods Corp.. Based in San Bernardino, Anita’s Mexican Foods has grown from modest beginnings into a leader in the food production industry under Gomez’s strategic direction.
The Spirit of the Entrepreneur Awards Gala continues to shine a spotlight on the transformative work of Inland Empire entrepreneurs, celebrating their innovation, resilience, and commitment to the community.
For more information about the Spirit of the Entrepreneur Awards, visit https://www.spiritawardsie.com.
For more details about the Inland Empire Regional Chamber of Commerce and its members, visit www.iechamber.org.
|
Business Journal Newsletter
|
-
Construction2 months agoTricon Residential Expands California Housing with New Built-to-Rent Community in Corona
-
Entertainment3 months agoMain Event Joins Inland Empire Regional Chamber of Commerce: Bringing Premier Family Entertainment to Montclair
-
Commercial Real Estate4 months agoValore Ventures Sells SoCal Single-Tenant NNN Retail Property
-
Business2 months agoStrengthening Community Connections: Our Exciting New Partnership with Toyota Arena, Ontario Convention Center, and GOCAL
-
Travel & Tourism3 months agoOntario International Airport to welcome STARLUX as its newest airline partner in June 2025
-
Travel & Tourism3 months agoOntario International Airport Expands Reach with New Daily Flights to Chicago O’Hare