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Murrieta Genomics Spinout simplSEQ Completes Seed Round Funding

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Company Plans Commercial Operations in 2021

Murrieta Genomics, the launchpad for genomic sequencing startups, has announced that simplSEQ, an incubator company, has completed its seed round funding, having received $2 million in total. Funds are to be used to validate the company’s novel sample preparation technology with external labs, further protect its patent-pending intellectual property and bring the first products to market.

“This is the amount we targeted to get to revenue generation,” stated John Powers, CEO of simplSEQ. “Our first product is a kit for the purification and isolation of nucleic acids from plasma that we believe will transform the genomic industry.” 

Powers went on to explain that simplSEQ is initially focused on  Nucleic Acid purification and Targeted Assays. The first product is designed to allow labs to isolate and purify virtually all DNA and RNA from biological samples in a completely different way than currently used. The company believes that its proprietary process will be a significant improvement over the existing conventions.

According to simplSEQ’s Chief Science Officer, Brandon Young, “My years at the bench led to a growing frustration with the status quo, accepting products with known issues and increasing complexity of sample preparation and I knew there had to be a better way. simplSEQ’s patent-pending approach eliminates error prone steps and improves turnaround time while reducing lab and labor costs.”

The first product being developed targets the fast-growing liquid biopsy segment. Targeted therapies based upon genomic biomarkers, disease recurrence monitoring, noninvasive pregnancy screening and early cancer screening are just a few of the areas this segment covers. Having a simple protocol that can improve cell free DNA yields while reducing PCR bias and eliminating hybridization and capture steps would be a significant advance. The simplSEQ process also co-purifies both DNA and RNA – enabling simultaneous downstream assays. In addition, no redesigned primers or informatics are needed. 

“The clinical use of the cell free DNA has expanded since the initial use with non-invasive prenatal testing. The use of liquid biopsy in oncology has significantly increased since the first commercially available multigene liquid biopsy platform became available in 2014,” stated Dr. John Spinosa, Chief Medical Officer of simplSEQ. “Today several assays with cfDNA in oncology are commercially available and FDA-approved, and a subset of these assays are considered sufficient for treatment eligibility by insurance companies. We expect to see high growth in the applications of cfDNA as precision medicine advances.”

Another market segment simplSEQ intends to transform is the targeted next generation sequencing assay market. This rapidly expanding area is producing new applications in areas such as transplant surveillance, oncology, rare diseases, population genetics and pathogen detection.

“Our process enables improved targeted sequencing by eliminating the need for ligation and reducing GC content bias. We only need a single PCR step, no capture steps and there are no complicated high temperature wash steps. This will eliminate the need for highly trained lab personnel while reducing labor and sequencing costs. Lab turnaround times will be significantly improved and by eliminating steps that may lead to errors, the labs should be able to improve data quality,” explained Young.

One feature that is unique to simplSEQ’s process is that the nucleic acids are covalently bound to a support structure as single strands. This enables complimentary copies of each strand to be made and eluted off. The eluted strands can then be used for testing. The original DNA or RNA remains bound to the solid support and can be reinterrogated. 

“As a pathologist, I am acutely aware of how precious samples can be,” said Dr. Spinosa. “The ability to preserve the original nucleic acid material while assaying a sample may eliminate the need for second biopsies if further interrogation is needed. One can go back to the original isolated sample. Dealing with scarce samples and limited time is becoming a larger and larger issue in the pathology community. The ability to test a nucleic acid sample in multiple ways while preserving the original material would be a huge benefit. One can easily envision step-wise assays and the potential of creating a biobank that patients can return to as their care may dictate.”

The company is currently in discussions with industry-leading organizations that have expressed a desire to evaluate the new technology and will thus provide validation on the data that has been generated internally by the company. Upon receiving data and feedback from these organizations, simplSEQ is prepared to go to market.

“We already have manufacturing, fulfillment, delivery and billing in place,” stated Powers. “We will have the ability to scale rapidly, as these operations are being outsourced to leaders in their respective areas. We also believe that many of our larger future customers will want to license the technology for use in their applications. This funding marks a pivotal step in simplSEQ’s development.”

Murrieta Genomics CEO, Jay Goth, stated “This is a perfect example of the kind of genomic sequencing companies we want to launch from our incubator. We are looking for transformational companies that can make an impact in this nascent space. Our advisory board has been instrumental and even critical to the development of simplSEQ. I can tell you that without the entire MG team simplSEQ would not be where it is today.”

The Inland Empire Business Journal (IEBJ) is the official business news publication of Southern California’s Inland Empire region - covering San Bernardino & Riverside Counties.

Business

Local Veteran and His Family Open New Graze Craze Charcuterie Business in Murrieta, California

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Southern California wine country gets another stylish culinary option, offering beautifully designed, hand-crafted grazing boards and picnic boxes

Graze Craze® has opened a new location close to the wine country of Southern California, where its artfully arranged sweet and savory grazing boards and boxes create a perfect pairing for food lovers. Located at 24530 Village Walk Place, Suite C, in Village Walk Plaza, the 1,021-square-foot store is owned and operated by disabled veteran Chris Stout and his wife, Stephanie Stout, with assistance from their teenage children.

At Graze Craze, highly trained experts known as Grazologists™ skillfully design charcuterie arrangements that feature an assortment of fine ingredients perfect for grazing, like fresh fruits and vegetables, premium meats and cheeses, artisanal sweets, nuts, house-made jams and more.

Chris Stout enlisted in the U.S. Navy in 2001 and served several deployments before being discharged in 2012. Since then, he has worked as a field service engineer for an electronics company and in manufacturing sales. Stephanie Stout has a bachelor’s degree in business accounting from the University of Phoenix and worked for an insurance broker before the couple’s first child was born; she then devoted herself full-time to raising their three children, who are now in high school.

Graze Craze charcuterie boards offer something for every lifestyle, dietary preference or palate and are available in a variety of size options to cater to any occasion, big or small. They incorporate a medley of flavors, like the fan-favorite Gone Grazey board, a perfectly balanced mix of cured meats, premium cheeses, crackers, fresh produce, nuts and more. The Vegegrazian is impeccably designed with a plethora of fresh fruits and vegetables for anyone embracing a plant-based lifestyle. Those with an undeniable sweet tooth can enjoy the Sweet & Grazey, a hand-crafted board featuring an abundance of delectable desserts like chocolates and baked goods paired with sweet dips to accent the irresistible flavors.

New to the Graze Craze menu is the Brunch Board, a gourmet and innovative twist on any morning routine. Packed with breakfast meats, fresh fruits, eggs, pastries and more, this board is the perfect bagel-and-donut brunch alternative. Grazers can also tackle watch-party cravings with a seasonal Game Day Board, featuring a feast of

crowd-pleasing ingredients, like peppered salami, Italian prosciutto, goat cheese, cranberry walnut bread, raspberry jam and chocolate bark, to name a few.

The artisan-inspired charcuterie offerings at Graze Craze are available in different size options, from Char-Cutie-Cups and Picnic Boxes for nibbling to sharing-size boards with enough fresh food to feed a large party. The food displays are ideal for elevating work meetings, family gatherings, lavish events and more, while they also make for memorable gifts that impress.

Besides sharing the flavorful menu with the area, the Stouts are actively involved in numerous local school, business and community organizations. The pair supports the Murrieta Valley High School Marching Band Boosters and California High School Rodeo Association District 8, in addition to the Boy Scouts of America California Inland Empire Council and Friends of Temecula Troop 309, where Christopher Stout is a part of the adult leadership team. The couple has also worked with Homes For Our Troops, an impactful nonprofit organization that builds specially adapted homes for post-9/11 disabled veterans.

Graze Craze Murrieta is open for pick-up, catering and free local delivery Monday through Saturday from 9 a.m. to 6 p.m. and Sunday from 10 a.m. to 2 p.m. For more information, call 951-942-7293.

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Partners in Action: How CalOSBA is bridging the gap in funding and resources for Inland Empire small businesses

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By Josaline Cuesta, California Program Director, Small Business Majority & IEBJ Content Contributor

For Tara Lynn Gray, Director of the California Office of the Small Business Advocate (CalOSBA), entrepreneurship has always been a core principle of her life. Her journey as an advocate for small businesses wasn’t built on textbooks, but on her family’s roots in small business ownership. As a young girl, she watched her grandmother empower and elevate Black women’s presences by styling their hair and instilling confidence in their personhood. She witnessed the direct impact of small businesses on community members in real time, and that’s always stayed with Tara.

As a key partner of Small Business Majority, she stands as a champion for the dreamers and risk-takers; the pillars of the communities across California and in the Inland Empire. I chatted with her to share more about her work at CalOSBA, what entrepreneurs can expect when they meet with a CalOSBA advisor, and the resources and community support available to help boost entrepreneurship in the Golden State.

Tell us about CalOSBA’s role in the small business community.

“California has the biggest small business community in the country, accounting for 4.1 million small businesses in 2023 alone. The overwhelming majority have no employees at all, except themselves, which means they don’t have a Board of Directors, expensive consultants, and they definitely don’t have lobbyists. I take my role as their advocate seriously, talking with and listening to small business owners from up and down the state. During the pandemic, we were under a very bright spotlight, administering nearly $5 billion in direct relief funding and we’re proud of the grant programs we still oversee. But that’s only a small part of what we do at CalOSBA.

My team connects small business owners to information and resources to help them get started, manage their business and, most importantly, to grow. If they’re looking for help, we want to be the first door they knock on. In addition, we offer Outsmart Disaster training, which focuses on how to mitigate risks associated with natural disasters and recovery avenues available to them. I always say the flagship of our office is our support for the statewide network of Small Business Centers, providing 1:1 business assistance and training for small business owners of all industries and in dozens of languages. In addition, supporting partners that deliver these services–all the federally funded centers like the Small Business Development Centers and the Women’s Business Centers but also Chambers of Commerce and other nonprofits—is a core function of my office. And a big source of pride because we know what a difference they make for their clients.”

What can small business owners expect from meeting with a California Small Business Center advisor?

“Small business owners can expect to meet someone who is fully invested in them. Our Centers cover the full spectrum of business needs, from writing a business plan and obtaining the right permits and licenses, to finding capital, planning a succession strategy and marketing to e-commerce. Our business advisors provide the experience and the objective perspective to help business owners optimize their best assets: ideas, energy, and ability to keep adapting and learning. And they do it because they love helping other people succeed. What’s more, business ownership can become isolating and it may be challenging for entrepreneurs to find assistance. But they don’t have to go at it alone–and they shouldn’t, when these no-cost and low-cost services are available to them.”

What’s the most rewarding part of your role at CalOSBA?

“I always say I have the best job in the state. And it’s because I frequently have the honor to watch someone’s dream come true. I love a ribbon-cutting ceremony–Every time, big or small. It means someone dreamed of accomplishing something and worked hard for it: They opened the doors to their business, they made a sale, and hopefully they will hire their first employee and then it’s off to the races. But no matter what happens to that business, that ribbon-cutting is a milestone they made happen for themselves. There are many other events I get invited to, where you can just see the hope and pride, and even fear in their faces. I’m often overwhelmed by the sheer emotion of it, and I’m always humbled that I get to participate in that person’s big milestone.”

What are some new programs that can benefit small business owners in the Inland Empire?

“The number one question my office gets asked is how to access small business financing. To help address this key need, we’re launching the Technical Assistance for Capital Readiness program this February. The program is part of a bigger effort to fill well-known funding gaps in the state to benefit very small businesses and Socially and Economically Disadvantaged Individuals (SEDI). Through investments from the U.S. Treasury, the State Treasurer’s Office and IBank, the program is going to support lenders to facilitate “high risk” loans that they normally would not approve.

In addition to supporting lenders, my office also received $25.3 million in U.S. Treasury funding to start the new Capital Readiness network. The Capital Readiness Coaches in this network will help business owners get ready for the lending marketplace, help them make the best choices in a high interest-rate environment, and optimize the use of the capital once they receive it. The network is also designed to help spread the word about this opportunity to these SEDI-owned businesses, and some of those partners will be focused on supporting the Inland Empire small business ecosystem.”

How can business owners get in touch with CalOSBA?

“That’s simple! Check out calosba.ca.gov and sign up for our monthly newsletter, where I write a column and showcase success stories from our network, along with deadlines and updates on grant and workforce support programs. We’re also on social media, so I would encourage business owners to check out all of our channels.”

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2024 Banking & Financial Industry Outlook: Where Knowledge Meets Opportunity in California’s Financial Landscape

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In an age where financial trends rapidly evolve and economic landscapes shift with increasing unpredictability, the Inland Empire Regional Chamber of Commerce stands as a beacon of knowledge and opportunity. It proudly announces its sold-out annual event, the Financial Industry Update, an exclusive gathering tailor-made for California and the Inland Empire region. This prestigious event is set to unfold on January 18, 2024, at the Ontario International Airport Authority Conference Center, promising an enriching experience for attendees.

A Gathering of Minds in the Financial Sphere

The Financial Industry Update is more than just an event; it’s a crucial nexus for professionals, businesses, and community leaders keen on gaining a deeper understanding of the financial nuances specific to California and the Inland Empire. This year’s event is particularly significant, given the rapid changes and challenges facing the financial sector in the region.

Keynote Speaker: A Treasury of Knowledge

Leading the charge is none other than California State Treasurer Fiona Ma, a figure renowned for her acumen in public finance, economic development, and responsible fiscal management. Her role as the keynote speaker underscores the event’s stature, offering invaluable insights into the financial future of California and the Inland Empire.

Featured Speakers: A Diverse Spectrum of Expertise

Joining Treasurer Ma is a lineup of distinguished speakers, each bringing unique perspectives and expertise:

  • Ivo Tjan: As the Chairman, President, and CEO of CommerceWest Bank, Tjan’s journey from founding the company to leading it through an IPO is nothing short of inspirational. His leadership and insights are eagerly anticipated.
  • Hilda Kennedy: The Founder/President of AmPac CDC and a trailblazer in local government and economic development, Kennedy’s impact on small businesses and community financing is profound.
  • Edward Ornelas, Jr.: The visionary force behind the Inland Empire Regional Chamber of Commerce, Ornelas’s innovative approaches to business and economic development have redefined the region’s business narrative.

Event Highlights: More Than Just Talks

The event promises more than just insightful presentations. It’s a unique opportunity for networking, where professionals can connect, collaborate, and engage with potential partners and influential community figures. The interactive Q&A sessions will allow attendees to delve deeper into subjects, clarifying doubts and gaining more profound knowledge.

A Confluence of Opportunity and Expertise

This event symbolizes the intersection of knowledge and opportunity in California’s dynamic financial landscape. It’s a platform where insights are shared, connections are made, and the future of the financial industry in the Inland Empire is contemplated and shaped.

As January 18 approaches, the anticipation among California’s financial community continues to build. This event is not just a meeting of minds; it’s a forge where the future of financial industry trends and strategies will be hammered out, shaping the economic future of the Inland Empire and beyond.

For more information about the event and the Inland Empire Regional Chamber of Commerce, visit www.iechamber.org

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