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Murrieta Genomics Spinout simplSEQ Completes Seed Round Funding



Company Plans Commercial Operations in 2021

Murrieta Genomics, the launchpad for genomic sequencing startups, has announced that simplSEQ, an incubator company, has completed its seed round funding, having received $2 million in total. Funds are to be used to validate the company’s novel sample preparation technology with external labs, further protect its patent-pending intellectual property and bring the first products to market.

“This is the amount we targeted to get to revenue generation,” stated John Powers, CEO of simplSEQ. “Our first product is a kit for the purification and isolation of nucleic acids from plasma that we believe will transform the genomic industry.” 

Powers went on to explain that simplSEQ is initially focused on  Nucleic Acid purification and Targeted Assays. The first product is designed to allow labs to isolate and purify virtually all DNA and RNA from biological samples in a completely different way than currently used. The company believes that its proprietary process will be a significant improvement over the existing conventions.

According to simplSEQ’s Chief Science Officer, Brandon Young, “My years at the bench led to a growing frustration with the status quo, accepting products with known issues and increasing complexity of sample preparation and I knew there had to be a better way. simplSEQ’s patent-pending approach eliminates error prone steps and improves turnaround time while reducing lab and labor costs.”

The first product being developed targets the fast-growing liquid biopsy segment. Targeted therapies based upon genomic biomarkers, disease recurrence monitoring, noninvasive pregnancy screening and early cancer screening are just a few of the areas this segment covers. Having a simple protocol that can improve cell free DNA yields while reducing PCR bias and eliminating hybridization and capture steps would be a significant advance. The simplSEQ process also co-purifies both DNA and RNA – enabling simultaneous downstream assays. In addition, no redesigned primers or informatics are needed. 

“The clinical use of the cell free DNA has expanded since the initial use with non-invasive prenatal testing. The use of liquid biopsy in oncology has significantly increased since the first commercially available multigene liquid biopsy platform became available in 2014,” stated Dr. John Spinosa, Chief Medical Officer of simplSEQ. “Today several assays with cfDNA in oncology are commercially available and FDA-approved, and a subset of these assays are considered sufficient for treatment eligibility by insurance companies. We expect to see high growth in the applications of cfDNA as precision medicine advances.”

Another market segment simplSEQ intends to transform is the targeted next generation sequencing assay market. This rapidly expanding area is producing new applications in areas such as transplant surveillance, oncology, rare diseases, population genetics and pathogen detection.

“Our process enables improved targeted sequencing by eliminating the need for ligation and reducing GC content bias. We only need a single PCR step, no capture steps and there are no complicated high temperature wash steps. This will eliminate the need for highly trained lab personnel while reducing labor and sequencing costs. Lab turnaround times will be significantly improved and by eliminating steps that may lead to errors, the labs should be able to improve data quality,” explained Young.

One feature that is unique to simplSEQ’s process is that the nucleic acids are covalently bound to a support structure as single strands. This enables complimentary copies of each strand to be made and eluted off. The eluted strands can then be used for testing. The original DNA or RNA remains bound to the solid support and can be reinterrogated. 

“As a pathologist, I am acutely aware of how precious samples can be,” said Dr. Spinosa. “The ability to preserve the original nucleic acid material while assaying a sample may eliminate the need for second biopsies if further interrogation is needed. One can go back to the original isolated sample. Dealing with scarce samples and limited time is becoming a larger and larger issue in the pathology community. The ability to test a nucleic acid sample in multiple ways while preserving the original material would be a huge benefit. One can easily envision step-wise assays and the potential of creating a biobank that patients can return to as their care may dictate.”

The company is currently in discussions with industry-leading organizations that have expressed a desire to evaluate the new technology and will thus provide validation on the data that has been generated internally by the company. Upon receiving data and feedback from these organizations, simplSEQ is prepared to go to market.

“We already have manufacturing, fulfillment, delivery and billing in place,” stated Powers. “We will have the ability to scale rapidly, as these operations are being outsourced to leaders in their respective areas. We also believe that many of our larger future customers will want to license the technology for use in their applications. This funding marks a pivotal step in simplSEQ’s development.”

Murrieta Genomics CEO, Jay Goth, stated “This is a perfect example of the kind of genomic sequencing companies we want to launch from our incubator. We are looking for transformational companies that can make an impact in this nascent space. Our advisory board has been instrumental and even critical to the development of simplSEQ. I can tell you that without the entire MG team simplSEQ would not be where it is today.”

The Inland Empire Business Journal (IEBJ) is the official business news publication of Southern California’s Inland Empire region - covering San Bernardino & Riverside Counties.


Inland Empire Regional Chamber of Commerce to Lead California Delegation at GITEX GLOBAL 2023 in Dubai



Fostering Technological Synergy: Bridging the Tech Gap with Global Partners

Demonstrating the Inland Empire Regional Chamber of Commerce’s (IERCC) commitment to global tech collaboration and innovation, the organization will lead a California delegation to the world-renowned GITEX GLOBAL event in Dubai from October 16-20, 2023. Though the original invitation extended to IERCC’s President & CEO, Mr. Edward Ornelas, Jr., he will not be in attendance. Instead, the California delegation will be spearheaded by the Chamber’s newly-appointed CTO, Mr. Gabriel Rangel.

Organized by the Dubai World Trade Centre, GITEX GLOBAL 2023 promises to be grander than ever. The event is set to host over 6,000 exhibiting companies and startups, drawing more than 170,000 tech and business executives from over 170 countries. The mega-event will sprawl across 41 vast halls and, for the first time ever, will be held at two prominent venues – the iconic Dubai World Trade Centre and the new Dubai Harbour for Expand North Star, making it the host for the world’s largest startup event.

Mr. Edward Ornelas, Jr. commented, “While I regret not attending GITEX personally, I am proud to have Mr. Rangel at the helm of this effort. I’m confident that our delegation will foster new collaborations and present the Golden State as a tech powerhouse.”

This year’s conference adopts the compelling theme of “The Year to Imagine AI in Everything”. Attendees are poised to witness the grandest showcase of AI tech giants and industry frontrunners. Additionally, it promises to kindle profound dialogues and debates concerning the socio-economic implications of burgeoning AI technology.

“Leading the California delegation at GITEX offers us an unmatched platform to nurture and solidify relationships with global tech partners,” said Mr. Gabriel Rangel, CTO of IERCC. “As the technology landscape continues to evolve, it’s critical for us to be a part of these international collaborations. I’m honored to spearhead this mission on behalf of the Inland Empire Regional Chamber of Commerce.”

An integral part of the California delegation, Mr. Ram Thanapandian, Principal Technology Consultant to the State of California and Chair of CA State Treasurer Fiona Ma’s Technical Advisory Commission, will be present, providing invaluable insights and representing the State of California Treasurer’s Office.

IERCC’s leadership in organizing this delegation underscores the crucial role that California plays in the global tech ecosystem and mirrors Dubai’s ambitious vision as encapsulated in the Dubai Economic Agenda (D33). This strategy aims to substantially expand Dubai’s economic landscape in the upcoming decade, securing its stature among the world’s leading global cities.

Trixie LohMirmand, Executive Vice President of the Dubai World Trade Centre and CEO of KAOUN International, remarked on the invaluable contributions the California delegation will bring to the event. She looks forward to an event marked by knowledge-sharing, collaboration, and pioneering discussions.

For additional information on GITEX GLOBAL 2023, please refer to: GITEX 2023 Preview.

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Economist Christopher Thornberg, State Treasurer Fiona Ma Headline New Forecast Conference



Coming October 5th

Economic Horizon 2024: What Lies Ahead?

The Inland Empire Regional Chamber of Commerce, in collaboration with Beacon Economics and the County of San Bernardino, is thrilled to announce that the anticipated economic forecast conference, Economic Horizon 2024: What Lies Ahead, Inland Empire? will be held October 5th from 3:30 PM to 6:30 PM at the El Prado Golf Courses in the vibrant city of Chino, California.

Esteemed economist, Dr. Christopher Thornberg will present complete outlooks for the U.S., California, and Inland Empire economies. “The Inland Empire stands at the crossroads of remarkable economic opportunities and challenges,” said Thornberg. “I’m excited to unpack the trends and shifts that will define the region’s economic landscape in the next year, and beyond.”

Known for his razor-sharp observations, and fun, energized delivery, Thornberg’s presentation will include pointed discussions about inflation, the Fed’s next move, housing markets, strengths and instabilities in the economy, and what current trends mean for the nation, state, and local region.

The conference will also be graced by the insights of California State Treasurer Fiona Ma as keynote speaker. In her words, “The strength of California’s economy is deeply interwoven with the growth trajectories of its regions. The Inland Empire, with its dynamism and resilience, is a testament to this synergy. I am honored to join ‘Economic Horizon 2024’ and share a vision where policies, partnerships, and potentials converge to elevate the Inland Empire to unprecedented economic heights.”

“This conference is a testament to the collaborative spirit of the Inland Empire and our commitment to fostering a robust, resilient economy,” said Edward Ornelas, Jr., President of the Inland Empire Regional Chamber of Commerce. “Our partnership with Beacon Economics and the County of San Bernardino aims to offer a platform for profound economic discussion, forecasting, and strategic future planning.”

Attendees can anticipate not only expert insights into the economy but also networking opportunities and a chance to connect with key business, government, and nonprofit leaders from across the region.

Full event details are available at:

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Bizz Buzz

Webb Investments acquires Silver Creek Industries, an industry leader in modular construction for schools



Webb Investments today announced the launch of a new company, Silver Creek Modular, after acquiring the assets of Silver Creek Industries, a highly respected modular construction company known for bringing innovative, sustainable and cost-effective solutions to the education industry. 

Silver Creek Industries’ existing business, including its employees and its Perris, Calif., manufacturing facility, will remain with the new company, with Webb providing the investment capital, resources and expertise to enhance Silver Creek’s presence in the modular construction marketplace.

The acquisition closed in June of 2023, following Silver Creek Industries’ Chapter 11 filing in the Central Bankruptcy Court of California.

“We are thrilled to have the opportunity to bring Silver Creek into our family business, and look forward to building on our shared commitment to improving educational opportunities within communities across our region,” said Kiana Webb, CEO of Webb Family Enterprises. “This acquisition aligns with our strategy to invest in established firms that can help us drive community revitalization and inclusive growth, while improving quality of life and increasing economic output.”

Silver Creek Industries was founded in 2004 and has completed more than 1,000 projects in the education, commercial, medical, military, government and multi-family housing markets. More recently, the company’s focus has been on providing high-quality, sustainable modular buildings for schools and educational institutions. Silver Creek Industries is well known for delivering projects on time and on budget, with minimal disruption to school and the community. 

Webb Investments is a privately held, family-owned company focusing on creating a community development ecosystem that drives inclusive, organic growth and transforms the areas they serve. 

For more information on Webb Investments, please visit

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